Results from nonclinical studies of Cidara’s lead candidate CD101 IV (formerly biafungin), a novel, long-acting echinocandin, will be presented this week at the 54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) meeting in Washington D.C. Four posters and one abstract regarding CD101 IV have been accepted for presentation.
Kieren Marr, M.D., professor of medicine and oncology, and director of the transplant and oncology infectious diseases program at the Johns Hopkins University School of Medicine and advisor to Cidara, stated, “There remains significant unmet need for novel drugs to treat life-threatening, invasive fungal infections. A long-acting echinocandin would represent a major addition to our antifungal repertoire by enabling easier completion of treatment without antifungal class switching, potentially enabling earlier discharge of patients and better prevention strategies in high risk patients.”
The presentations are as follows:
Sunday, September 7th
Poster Presentations 082 – Pharmacokinetics/Pharmacodynamics of Antifungal Agents
(11:00 a.m. – 1:00 p.m.)
- A-693: CD101, a Novel Echinocandin, Displays an Uncommonly Long Half-life in Multiple Species; K. James, R. Krishnan, C. Laudeman, K. Polowy, A. Vaidya
- A-694: CD101, a Novel Echinocandin, Displays a Long Half-life in the Chimpanzee, Suggesting a Once-Weekly IV Dosing Option; K. James, R. Krishnan, S. Smith, C. Laudeman, K. Polowy, A. Vaidya
Poster Presentations 109 – Fungal Epidemiology (11:00 a.m. – 1:00 p.m.)
- M-1082: Activity Of A Novel Echinocandin CD101 Tested Against Most Common Candida And Aspergillus Species, Including Echinocandin- And Azole-resistant Strains; M. Castanheira, S. Messer, P. Rhomberg, R. Jones, M. Pfaller
Monday, September 8th
Poster Presentation 171 – New Antifungal Agents on the Horizon (11:00 a.m. – 1:00 p.m.)
- F-1592: CD101, a Novel Echinocandin, Displays Excellent Stability in Plasma, Aqueous Solution, and at Elevated Temperature; R. Krishnan, K. James, S. Smith, C. Laudeman, A. Vaidya, B. Bryant, K. Polowy
Published Abstract:
- Single-dose Pharmacokinetics of CD101, a Novel Echinocandin, after Subcutaneous Administration in Rat and Monkey; K. James, R. Krishnan, K. Polowy, C. Laudeman
